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HESI A2 Anatomy and Physiology Practice Questions

15 free questions from the CinnaEntry HESI A2 anatomy and physiology bank (280 in the app). Tap an answer to check it. The rationale opens right away.

15 questions Rationale on every answer Updated October 17, 2026
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  1. Q1 / 15 Correct Not quite

    The respiratory and circulatory systems work together to supply the body with:

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    Answer: B. Oxygen

    The lungs take in oxygen and the blood transports it to the body's cells.

  2. Q2 / 15 Correct Not quite

    The frontal lobe of the brain is mainly responsible for:

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    Answer: B. Thinking, planning, and decision-making

    The frontal lobe handles higher functions like reasoning, planning, and voluntary movement.

  3. Q3 / 15 Correct Not quite

    The pigment that gives skin its color and helps protect against UV light is:

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    Answer: B. Melanin

    Melanin, produced in the epidermis, gives skin color and absorbs harmful UV radiation.

  4. Q4 / 15 Correct Not quite

    The skeletal system stores which mineral important for strong bones?

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    Answer: B. Calcium

    Bones store calcium (and phosphorus), releasing it into the blood as the body needs it.

  5. Q5 / 15 Correct Not quite

    The hormone that helps regulate sleep, secreted by the pineal gland, is:

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    Answer: B. Melatonin

    Melatonin from the pineal gland helps regulate the sleep–wake cycle.

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  7. Q6 / 15 Correct Not quite

    Which gland is called the 'master gland' because it regulates other endocrine glands?

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    Answer: A. Pituitary gland

    The anterior pituitary secretes tropic hormones (TSH, ACTH, FSH, LH) that direct other glands. It is itself directed by the hypothalamus.

  8. Q7 / 15 Correct Not quite

    The body's first physical barrier against most pathogens is the:

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    Answer: B. Skin

    Intact skin is the body's first line of defense, blocking pathogens from entering.

  9. Q8 / 15 Correct Not quite

    Which valve prevents backflow from the left ventricle into the left atrium?

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    Answer: A. Mitral (bicuspid) valve

    The mitral (bicuspid) valve sits between the left atrium and left ventricle. The tricuspid does the same job on the right side; the aortic and pulmonic are the semilunar outflow valves.

  10. Q9 / 15 Correct Not quite

    Which gland regulates blood calcium by raising it when levels fall?

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    Answer: A. Parathyroid gland

    Parathyroid hormone raises calcium; calcitonin (from the thyroid) lowers it. The two work as opposites.

  11. Q10 / 15 Correct Not quite

    Which vessel type is the site of gas and nutrient exchange?

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    Answer: A. Capillaries

    Capillaries have walls one cell thick, which is what allows oxygen, nutrients and wastes to diffuse across. Arteries and veins transport blood but do not exchange across their walls.

  12. Q11 / 15 Correct Not quite

    During pregnancy, the fetus receives nutrients from the mother through the:

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    Answer: A. Umbilical cord

    The umbilical cord connects the fetus to the placenta, delivering nutrients and oxygen.

  13. Q12 / 15 Correct Not quite

    The smallest bone in the human body, located in the ear, is the:

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    Answer: B. Stapes

    The stapes (stirrup) in the middle ear is the smallest bone in the body.

  14. Q13 / 15 Correct Not quite

    Which nutrient is most important for building and repairing muscle after exercise?

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    Answer: B. Protein

    Protein provides amino acids used to build and repair muscle tissue.

  15. Q14 / 15 Correct Not quite

    After a meal, the pancreas releases ____ to lower blood sugar.

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    Answer: B. Insulin

    Insulin lowers blood glucose after eating; glucagon raises it when levels drop.

  16. Q15 / 15 Correct Not quite

    Which best describes the relationship 'cells → tissues → organs → organ systems'?

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    Answer: B. Levels of organization from smallest to largest

    This is the biological hierarchy of organization, moving from the smallest unit (cells) to the largest (organ systems).

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