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HESI Anatomy & PhysiologyWhat a spun sample separates into

Blood ComponentsHESI A2 cheat sheet

Blood is a tissue, not just a fluid. Spun in a centrifuge it separates into three visible layers, and each layer has a job the exam asks about directly.

22 key facts 5 practice questions Reviewed Oct 2026
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By Volume

  • Plasma ≈ 55% — mostly water, plus proteins, nutrients, wastes
  • Red cells ≈ 45% — this figure IS the hematocrit
  • White cells + platelets < 1% — the thin buffy coat

What Each One Does

  • Erythrocytes (red) — carry O₂ on hemoglobin
  • Leukocytes (white) — fight infection
  • Thrombocytes (platelets) — clotting
  • Plasma — transport medium and clotting proteins

Worth Memorizing

  • Hemoglobin is the iron-containing protein that binds O₂
  • Red cells have NO nucleus at maturity — more room for hemoglobin
  • Blood is a connective TISSUE, not just a fluid
Key takeaway

Plasma is about 55% of blood volume — mostly water, plus proteins, nutrients, hormones and wastes.

Before you read

Test yourself first: 5 questions

Question 1 of 5

Which blood vessel carries oxygenated blood from the lungs back to the heart?

Key points

  • Plasma is about 55% of blood volume — mostly water, plus proteins, nutrients, hormones and wastes.
  • Red blood cells (erythrocytes) are about 45% and carry oxygen on hemoglobin; that 45% figure is the hematocrit.
  • White blood cells (leukocytes) fight infection and are less than 1% of volume.
  • Platelets (thrombocytes) are cell fragments that begin clotting.
  • Red cells are made in RED bone marrow; yellow marrow stores fat.

Study first

  1. A patient's hematocrit is reported as 45%. That means red cells occupy 45% of the blood volume — a normal adult value.
  2. An infection raises the white cell count; it does not raise the hematocrit, because those are different components.

Commonly tested

  • Picture the spun tube: straw-colored plasma on top, a thin pale band, dark red cells at the bottom. The picture gives you the percentages.
  • Match each component to ONE verb: plasma carries, red cells oxygenate, white cells defend, platelets clot.

Watch out for

  • Confusing plasma (the liquid, still containing clotting factors) with serum (plasma after clotting).
  • Assigning oxygen transport to white cells — that is the red cells' job.
  • Calling platelets whole cells; they are fragments of larger cells.

Blood Components: FAQs

What should I focus on first when studying Blood Components?

A patient's hematocrit is reported as 45%. That means red cells occupy 45% of the blood volume — a normal adult value. An infection raises the white cell count; it does not raise the hematocrit, because those are different components.

What is most often missed on Blood Components?

Confusing plasma (the liquid, still containing clotting factors) with serum (plasma after clotting). Assigning oxygen transport to white cells — that is the red cells' job. Calling platelets whole cells; they are fragments of larger cells.

What do I need to know about Blood Components for the HESI A2?

Plasma is about 55% of blood volume — mostly water, plus proteins, nutrients, hormones and wastes. Red blood cells (erythrocytes) are about 45% and carry oxygen on hemoglobin; that 45% figure is the hematocrit. White blood cells (leukocytes) fight infection and are less than 1% of volume. Platelets (thrombocytes) are cell fragments that begin clotting.

What are the most commonly tested points on Blood Components?

Picture the spun tube: straw-colored plasma on top, a thin pale band, dark red cells at the bottom. The picture gives you the percentages. Match each component to ONE verb: plasma carries, red cells oxygenate, white cells defend, platelets clot.

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