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HESI Anatomy & PhysiologyWhat shifts with age

Changes Across the LifespanHESI A2 cheat sheet

What shifts with age

8 key facts 3 practice questions Reviewed Oct 2026
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Cardiovascular

  • Vessels stiffen; blood pressure tends to rise
  • Maximum heart rate falls

Musculoskeletal

  • Bone density declines; muscle mass and strength fall
  • Joint cartilage thins

Sensory & Neuro

  • Hearing and vision decline; reaction time slows
  • Thirst sensation decreases — dehydration risk

Renal & Immune

  • Filtration rate falls — drug clearance slows
  • Immune response weakens
Key takeaway

What shifts with age

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Question 1 of 3

Gas exchange in the lungs occurs across the:

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