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HESI Anatomy & PhysiologyThe major ions

Fluid & Electrolyte BalanceHESI A2 cheat sheet

The major ions

10 key facts 5 practice questions Reviewed Oct 2026
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Compartments

  • About 60% of adult body weight is water
  • Intracellular — inside cells (the majority)
  • Extracellular — plasma and interstitial fluid

Key Electrolytes

  • Sodium — main extracellular ion, drives water movement
  • Potassium — main intracellular ion, critical to the heart
  • Calcium — bone, clotting, muscle contraction
  • Bicarbonate — the main pH buffer

Movement

  • Water follows sodium
  • Osmosis moves water toward the higher solute concentration

Regulation

  • Kidneys, ADH and aldosterone do most of the work
Key takeaway

The major ions

Before you read

Test yourself first: 5 questions

Question 1 of 5

Most nutrient absorption occurs in the:

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